CRF(POMC) in PSSD and PFS and PTSD ( differences)

Helen

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Oct 5, 2017
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#1
Let me start by mentioning what CRF does.


CRF attaches to CRF1 receptors which then releases POMC Proopiomelanocortin - Wikipedia Also it can act on CRF2 receptors.

POMC breaks down into

1) ACTH
2) A-MSH( remember the PT-141 which helped some with erections. Also responsible for hair color which is affected in PFS. And ant inflammatory and saves skin. https://www.hindawi.com/journals/bmri/2014/874610/
3) opiods , beta endorphins.
4) Lipotropin - Wikipedia this one is very interesting, since it controls lipid-mobilizing functions such as lipolysis[1] and steroidogenesis. I guess this is why when people take cortisol and suppress POMC they can get fatty liver.
Lipotropin is metabolized into endorphins that can greatly affect mood and behavior and is thus regarded as a prohormone

These are all released at the same time during stress, and this takes off the pressure of catecholamines Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression


As you can see this is quite interesting that all of these areas are highly affected in PFS, like hair color many people complain of hair going red, fatty liver insulin resistance. mood. stress response.


1) PFS

it is possible than androgen receptor is overxpressed in the brain in DHT sensitive tissues, and this totally suppresses CRH1 receptors Mrna.

GABA also suppresses this receptor. ESTROGEN increases this receptor.


CRH and ACTH increase allopregnenolone.
Effects of CRH and ACTH administration on plasma and brain neurosteroid levels. - PubMed - NCBI

Very interesting study about Estrogen and AR receptor control of CRH.
Androgen regulation of corticotropin-releasing hormone receptor 2 (CRHR2) mRNA expression and receptor binding in the rat brain

Dihydrotestosterone differentially modulates the cortisol response of the hypothalamic-pituitary-adrenal axis in male and female rhesus macaques, and restores circadian secretion of cortisol in females

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Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis

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CRF1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse



2) PSSD

Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala

Downregulated CRF receptors and upregulated GR.





3) PTSD

In PTSD cortisol is low and ACTH is lower, and CRF levels are high,

(PDF) The ACTH response to dexamethasone in PTSD


GR is overexpressed.

This is a little more similar to PSSD.


Opiods taken after stressfull event help PTSD people not to get PTSD. I guess you can see why , since opiods would inhibit ACTH

also high level of CRF could tell us that CRF1 receptor is weak.




SO I think there is some involvement of this system in PFS, PSSD, high or low CRF


@Boris @MCurtone
 
Last edited:
Oct 27, 2017
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#2
As you can see this is quite interesting that all of these areas are highly affected in PFS, like hair color many people complain of hair going red, fatty liver insulin resistance. mood. stress response.

!?!?

"
Would you rather have fiery red locks or hair of gray? For some animals, a grizzled look may be a sign of health, new research finds.

Wild boars with reddish coats have more cell damage than more mundanely colored wild pigs, Spanish researchers report in the July/August issue of the journal Physiological and Biochemical Zoology. The reason seems to be that the production of red pigment uses up an antioxidant that could otherwise be chasing down the free radicals that damage cells.

There are two types of melanins, the pigments that lend hair and skin their color. Eumelanins are brown or black, while pheomelanins produce bright red or rich chestnut hues. Unlike eumelanin, pheomelanin requires a chemical called glutathione, or GSH, to produce the color.

GSH is an antioxidant, meaning it can halt the chemical reaction of oxidation. Oxidation reactions cause free radicals, which in turn cause cellular damage.

Galván and his colleagues wanted to know whether producing red hair would eat up GSH, leaving the body's cells more vulnerable to free radicals. They tested wild boars from southwestern Spain for oxidative stress, a measure of free radical damage.

They found that the more pheomelanin a boar had in its fur, the more likely it was to have less GSH in the muscle cells and more oxidative stress.

"This suggests that certain colorations may have important consequences for wild boars," Galván said. "Pheomelanin responsible for chestnut colorations may make animals more susceptible to oxidative damage."

Meanwhile, gray hair, which results from an absence of melanin, seemed to be a mark of good health in wild boars.

"As with human hair, wild boars show hair graying all across their body fur," Galván said. "But we found that boars showing hair graying were actually those in prime condition and with the lowest levels of oxidative damage. Far from being a sign of age-related decline, hair graying seems to indicate good condition in wild boars."

"
 
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Oct 27, 2017
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#4
@supernature that's exactly why The Witcher is so strong, grey hair is just a sign of mutation to superior health and strength, they knew it LOL!

Yeah this guy looks like hes been on some pushups regimen for a while besides the oatmeal every 3 hours :)). I hear this for a first time grey hair is a sign of health as obviously is missing some that body requires, also for the red hair that is assoc with greater use of glutathione even so the opposite make more sense.

This movie seems fairly new, never watch it, it might be good. Im more into older movies atm after watching Mad MAx the last one few yrs back and lately again i decided should play the '79, '81, '85 productions next, cause never saw those.